abstract：:Hepatic metallothionein (MT) expression, with various isoforms, and varying cellular localizations is a useful marker for clinico-pathogenesis of liver diseases. In acute liver toxicity caused by cadmium, carbon tetrachloride, or acetaminophen, MT plays a protective role, via the scavenging of radical species. In chro...

journal_title：Current pharmaceutical biotechnology

authors： Nagamine T,Nakajima K

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:RA is one of autoimmune diseases, has drawn great attention of the world. Currently, the anti- IL-1β monoclonal antibody Canakinumab (ACZ885) for treatment of RA has entered into clinical trials. However, Full length antibody has large molecular weight, and is difficult to penetrate the tissue or the nidus. I...

journal_title：Current pharmaceutical biotechnology

authors： Li T,Xu L,Ren G,Yin C,Zhou B,Ye X,Li Q,Li N,Li D

更新日期：2013-01-01 00:00:00

abstract：:Raman spectroscopy has long been used as a powerful tool for chemical composition analyses. Raman scattering light measurement has the advantage of being able to examine biomolecules in a nondestructive and non-labeling manner. However, molecular imaging of cells and tissues by using Raman microscopy had been hampered...

journal_title：Current pharmaceutical biotechnology

authors： Harada Y,Takamatsu T

更新日期：2013-01-01 00:00:00

abstract：:Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics. Monitoring a protein's HOS is crucial towards understanding the impact of molecular conformation on the biotechnological application. In addition, maintaining the HOS is...

journal_title：Current pharmaceutical biotechnology

authors： Nagarkar RP,Murphy BM,Yu X,Manning MC,Al-Azzam WA

更新日期：2013-01-01 00:00:00

abstract：:Midkine is a heparin-binding growth factor that promotes cell growth, survival, and migration. Externally added midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction in the mouse. Preclinical testing of this protein is in progress. Externally added pleiotrophin, a member o...

journal_title：Current pharmaceutical biotechnology

authors： Murasugi A

更新日期：2013-01-01 00:00:00

abstract：:Currently dengue is a serious disease which has become a global burden in the last decade. Unfortunately, there are no effective drugs and vaccines against this disease. DENV non-structural protein (NS) 3, which is viral protease which is a potential target for antiviral therapy. Targeting this we performed homology m...

journal_title：Current pharmaceutical biotechnology

authors： Parida P,Yadav RN,Sarma K,Nainwal LM

更新日期：2013-01-01 00:00:00

abstract：:Clostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site is found and a C-te...

journal_title：Current pharmaceutical biotechnology

authors： Nagahama M

更新日期：2013-01-01 00:00:00

abstract：:Tumor cells show metabolic features distinctive from normal tissues, with characteristically enhanced aerobic glycolysis, glutaminolysis and lipid synthesis. Peroxisome proliferator activated receptor α (PPAR α) is activated by nutrients (fatty acids and their derivatives) and influences these metabolic pathways actin...

journal_title：Current pharmaceutical biotechnology

authors： Grabacka M,Pierzchalska M,Reiss K

更新日期：2013-01-01 00:00:00

abstract：:Oncogene-driven proliferative signaling in tumor cells requires comprehensive upregulation of cellular energy metabolism and macromolecule syntheses. These alterations are now known to include not only upregulated glycolysis, but also increased fatty acid metabolism, glutaminolysis, deregulated mitochondrial function ...

journal_title：Current pharmaceutical biotechnology

authors： Shoshan MC

更新日期：2013-01-01 00:00:00

abstract：:In order to valorize novel biotechnology innovations, there is a need to evaluate ex-ante their market potential. A case in point is biofortification, i.e. the enhancement of the micronutrient content of staple crops through conventional or genetic breeding techniques. In a recent article in Nature Biotechnology, for ...

journal_title：Current pharmaceutical biotechnology

authors： De Steur H,Blancquaert D,Gellynck X,Lambert W,Van Der Straeten D

更新日期：2012-12-01 00:00:00

abstract：:In many signaling pathways, various factors have been isolated by molecular genetic studies and wholegenome analysis. Understanding the interactions among these factors is crucial to understanding the signaling process as a whole. Recent studies on auxin signaling in the regulation of plant growth and development have...

journal_title：Current pharmaceutical biotechnology

authors： Muto H,Kinjo M

更新日期：2012-11-01 00:00:00

abstract：:The interaction between reactive oxygen species (ROS) and inflammation plays an important role in the pathogenesis of endothelial dysfunction and cardiovascular disease, cancer and other diseases. Thus, antioxidant strategies may be important in immune regulation and in limiting inflammation. Surprisingly, large clini...

journal_title：Current pharmaceutical biotechnology

authors： Spychalowicz A,Wilk G,Śliwa T,Ludew D,Guzik TJ

更新日期：2012-10-01 00:00:00

abstract：:Medical applications of ultrasound were first investigated about seventy years ago. It has rapidly evolved since then, becoming an essential tool in medical imaging. Ultrasound ability to provide real time images with frame rates exceeding several hundred frames per second allows one to view rapid anatomical changes a...

journal_title：Current pharmaceutical biotechnology

authors： Azhari H

更新日期：2012-09-01 00:00:00

abstract：:Control of VEGF signaling is an intense objective of pre-clinical and clinical studies in HCC disease with steadily increasing clinical application. Despite its emerging role, several aspects of anti-VEGF based treatments are poorly investigated, like the impact on tumor cells themselves, such as the effect on intrace...

journal_title：Current pharmaceutical biotechnology

authors： Raskopf E,Vogt A,Decker G,Hirt S,Daskalow K,Cramer T,Standop J,Gonzalez-Carmona MA,Sauerbruch T,Schmitz V

更新日期：2012-09-01 00:00:00

abstract：:The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytos...

journal_title：Current pharmaceutical biotechnology

authors： Lu W

更新日期：2012-09-01 00:00:00

abstract：:The accidental or intentional release of plutonium or americium can cause acute and long term adverse health effects if they enter the human body by ingestion, inhalation, or injection. These effects can be prevented by rapid removal of these radionuclides by chelators such as calcium or zinc diethylenetriaminepentaac...

journal_title：Current pharmaceutical biotechnology

authors： Kazzi ZN,Heyl A,Ruprecht J

更新日期：2012-08-01 00:00:00

abstract：:Gene therapy is a potential treatment for severe inherited disorders for which there is little hope of finding a conventional cure. These include lethal diseases like immunodeficiencies and metabolic disorders, and non lethal conditions associated to poor quality of life and life-long symptomatic treatments, like musc...

journal_title：Current pharmaceutical biotechnology

authors： Cavazza A,Mavilio F

更新日期：2012-08-01 00:00:00

abstract：:Herpes simplex virus (HSV) is a well-known vector that is often used for gene therapy to treat cancers. The most attractive feature of HSV is its ability to destroy tumors through a distinctive oncolytic mechanism where the virus can destroy cancer cells via cell lysis, a killing function that no anti-cancer drugs can...

journal_title：Current pharmaceutical biotechnology

authors： Wong J,Lee C,Zhang K,Rennie PS,Jia W

更新日期：2012-07-01 00:00:00

abstract：:Natural compounds represent a significant source for the development of novel medicines. Finding the target proteins for a natural compound is the most important step towards understanding its molecular mechanism for therapeutic usage. In fact, the search for target proteins could be considered the first step of the d...

journal_title：Current pharmaceutical biotechnology

authors： Yao L

更新日期：2012-07-01 00:00:00

abstract：:Platelet concentrates for surgical use are innovative tools of regenerative medicine, and were widely tested in oral and maxillofacial surgery. Unfortunately, the literature on the topic is contradictory and the published data are difficult to sort and interpret. In bone graft, implant and reconstructive surgery, the ...

journal_title：Current pharmaceutical biotechnology

authors： Simonpieri A,Del Corso M,Vervelle A,Jimbo R,Inchingolo F,Sammartino G,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00

abstract：:The recent developement of platelet concentrate for surgical use is an evolution of the fibrin glue technologies used since many years. The initial concept of these autologous preparations was to concentrate platelets and their growth factors in a plasma solution, and to activate it into a fibrin gel on a surgical sit...

journal_title：Current pharmaceutical biotechnology

authors： Bielecki T,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00

abstract：:Over the last 50 years, evidence for central involvement of glutamatergic neurotransmission in the pathophysiology of schizophrenia has accumulated. Recent advances in neuroimaging technology now allow several components of glutamatergic neurotransmission to be assessed in the living human brain. Positron emission tom...

journal_title：Current pharmaceutical biotechnology

authors： Egerton A,Stone JM

更新日期：2012-06-01 00:00:00

abstract：:Schizophrenia is a severe mental disorder, characterized by a complex symptomatology and a chronic relapsing course, leading to a more or less intensive residual syndrome. The disorder has strong consequences on social functioning and on the patients' quality of life and is associated with a huge economical burden for...

journal_title：Current pharmaceutical biotechnology

authors： Moller HJ

更新日期：2012-06-01 00:00:00

abstract：:More than 80% of all cancers are caused by solid malignancies. More than 90% of these tumours are of epithelial origin. The main principles in tumour treatment are surgery, radiotherapy, chemotherapy or combinations of these. Complete surgical removal of the tumour is the most effective therapy for solid malignancies....

journal_title：Current pharmaceutical biotechnology

authors： Mauerer R,Gruber R

更新日期：2012-06-01 00:00:00

abstract：:Unlike any other cell type, T cells have a unique potential to eliminate cancer cells and to eventually cure cancer patients. As a result, researchers have made extensive efforts over the past three decades to develop therapeutics with the potential to mount T cell responses against cancer cells. One way in which such...

journal_title：Current pharmaceutical biotechnology

authors： Baeuerle PA,Itin C

更新日期：2012-06-01 00:00:00

abstract：:Hyaluronan (HA) is a highly biocompatible biopolymer that is widely used for a variety of therapeutic purposes including surgical preparations, adhesion prevention, viscosupplementation and drug and cytokine delivery. Delivery can be accomplished effectively when HA-based carriers are synthesized in the form of hydrog...

journal_title：Current pharmaceutical biotechnology

authors： Peattie RA

更新日期：2012-06-01 00:00:00

abstract：:Carbon monoxide (CO) has long been considered a purely toxic by-product of incomplete combustion processes. Acute exposure to high concentrations of CO is one of the leading causes of fatal poisoning in industrial countries. However, after two decades of intensive research, there is ample evidence that CO endogenously...

journal_title：Current pharmaceutical biotechnology

authors： Schmidt R,Ryan H,Hoetzel A

更新日期：2012-05-01 00:00:00

abstract：:A review of the developments on the analysis of residues of avermectins and milbemycins (both macrocyclic lactones) is presented. The macrocyclic lactones (MLs) are an important class of chemicals, which are used worldwide as veterinary drugs and as crop protection agents. As a result, residues of MLs are important fr...

journal_title：Current pharmaceutical biotechnology

authors： Danaher M,Radeck W,Kolar L,Keegan J,Cerkvenik-Flajs V

更新日期：2012-05-01 00:00:00

abstract：:Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which it has widely proved its efficacy. While re...

journal_title：Current pharmaceutical biotechnology

authors： González P,González FA,Ueno K

更新日期：2012-05-01 00:00:00

abstract：:CNS disorders are the third major problem of health in developed countries, with approximately 10% of direct costs associated with a pharmacological treatment of doubtful cost-effectiveness. There is an alarming abuse of psychotropic drugs worldwide and only 20-30% of patients with CNS disorders appropriately respond ...

journal_title：Current pharmaceutical biotechnology

authors： Cacabelos R,Martinez-Bouza R,Carril JC,Fernandez-Novoa L,Lombardi V,Carrera I,Corzo L,McKay A

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Previous studies in humans concluded that a multigenic model including specific FSHR, ESR1 and ESR2 genotype patterns may partially explain the poor response to FSH. The aim of our study is to analyse three different loci -polymorphisms in ESR1 Pvu II, ESR2 Rsa I and Ser680Asn FSH receptor gene- in a Greek popu...

journal_title：Current pharmaceutical biotechnology

authors： Anagnostou E,Mavrogianni D,Theofanakis C,Drakakis P,Bletsa R,Demirol A,Gurgan T,Antsaklis A,Loutradis D

更新日期：2012-03-01 00:00:00

abstract：:Bone is among the most common locations of metastasis and therefore represents an important clinical target for diagnostic follow-up in cancer patients. In the pathogenesis of bone metastases, disseminated tumor cells proliferating in bone interact with the local microenvironment stimulating or inhibiting osteoclast a...

journal_title：Current pharmaceutical biotechnology

authors： Bauerle T,Komljenovic D,Semmler W

更新日期：2012-03-01 00:00:00

abstract：:The growing prevalence of disorders of lipid and sterol homeostasis such as obesity and atherosclerosis in Western societies has increased demand for the development of therapies for their prevention and treatment. Crucial for this development is an understanding of the underlying cellular mechanisms which are involve...

journal_title：Current pharmaceutical biotechnology

authors： Traini M,Jessup W

更新日期：2012-02-01 00:00:00

abstract：:Cancer is one of the leading causes of death in the United States and accounts for approximately 8 million deaths per year worldwide. Although there is an increasing number of therapeutic options available for patients with cancer, their efficacy is time-limited and non-curative. Approximately 50-60% cancer patients i...

journal_title：Current pharmaceutical biotechnology

authors： Gutheil WG,Reed G,Ray A,Anant S,Dhar A

更新日期：2012-01-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (also known as statins) are drugs active in the blockade of cholesterol synthesis and thus lowering cholesterol serum levels. Since their discovery, experimental evidence showed that statins strongly reduced atherogenesis and the risk of acute ischem...

journal_title：Current pharmaceutical biotechnology

authors： Montecucco F,Quercioli A,Mirabelli-Badenier M,Viviani GL,Mach F

更新日期：2012-01-01 00:00:00

abstract：:Pathophysiological changes are common in critically ill patients, and can alter the time course of drug concentrations following dosing. The latter is termed pharmacokinetics (PK), and describes the relationship between dose administered and drug concentrations in plasma. Thus, modifications in PK necessitate dose adj...

journal_title：Current pharmaceutical biotechnology

authors： Patel K,Kirkpatrick CM

更新日期：2011-12-01 00:00:00

abstract：:TGF-β isoforms (TGF-β1, -β2, and -β3) are secreted signaling ligands that stimulate the expression of protein components of the extracellular matrix, regulate the growth and differentiation of epithelial cells, modulate immune cell function, and play roles in the development of several essential organs, including the ...

journal_title：Current pharmaceutical biotechnology

authors： Hinck AP,O'Connor-McCourt MD

更新日期：2011-12-01 00:00:00

abstract：:Progress in many therapies, in particular in the therapies based on peptides, proteins and nucleic acids used as bioactive compounds, strongly depends on development of appropriate carriers which would be suitable for controlled delivery of the intact abovementioned compounds to required tissues, cells and intracellul...

journal_title：Current pharmaceutical biotechnology

authors： Slomkowski S,Gosecki M

更新日期：2011-11-01 00:00:00

abstract：:The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation of metastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by the need for cell motility, invasiveness, handling the shear stress in the vasculature and l...

journal_title：Current pharmaceutical biotechnology

authors： Gueron G,De Siervi A,Vazquez E

更新日期：2011-11-01 00:00:00

abstract：:Interleukin (IL)-7 is a cytokine inducing the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. As a consequence of IL-7 activating this pathway, STAT5 is phosphorylated. In pharmaceutical quality control, the potency of biopharmaceuticals is commonly assessed by proliferation assays....

journal_title：Current pharmaceutical biotechnology

authors： Zumpe C,Engel K,Wiedemann N,Metzger AU,Pischetsrieder M,Bachmann CL

更新日期：2011-10-01 00:00:00